Oxtr^tm1.1Knis
Targeted Allele Detail

Summary

• Symbol: Oxtr^tm1.1Knis
• Name: oxytocin receptor; targeted mutation 1.1, Katsuhiko Nishimori
• MGI ID: MGI:3608706
• Synonyms: OTR KO
• Gene: Oxtr Location: Chr6:112450644-112466904 bp, - strand Genetic Position: Chr6, 52.27 cM, cytoband E3
• Alliance: Oxtr^tm1.1Knis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102924
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-Neo cassette was inserted into intron 3 and three loxP sites around exons 2 and 3 and the PGK-Neo. Chimeras were mated to Tg(ACTB-cre)13Miya mice to remove exons 2 and 3 and the PGK-Neo cassette. Northern blot analysis and RT-PCR confirmed absence of RNA. (J:102924)

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oxtr Mutation: 40 strains or lines available

References

• Original: J:102924 Takayanagi Y, et al., Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16096-101
• All: 23 reference(s)