Gabrp^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Gabrp^tm1Dgen
• Name: gamma-aminobutyric acid type A receptor subunit pi; targeted mutation 1, Deltagen
• MGI ID: MGI:3604585
• Gene: Gabrp Location: Chr11:33500781-33528959 bp, - strand Genetic Position: Chr11, 19.21 cM
• Alliance: Gabrp^tm1Dgen page

Mutation origin

• Mutant Cell Line: 6646
• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in the gallbladder, moderate levels in lung, skin, seminal vesicle, prostate gland, ovary and uterus and low levels in subcortical region, olfactory bulb, eye, Harderian glands, liver, pancreas, kidney, thymus, urinary bladder, pituitary gland, salivary gland, tongue, stomach, small intestine, large intestine, cecum, testis, epididymis, coagulating gland and white fat. Beta-galactosidase expression from this allele is detectable in brain, spinal cord, thymus, lung, liver, pancreas, kidney, trachea, skeletal muscle, skin, testis, uterus and cervix. Most striking expression was detected in bronchial and tracheal epithelium. Staining was observed in different tissue and cell types, including epithelium and neurons.

Expression

In Mice Carrying this Mutation:

40 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gabrp Mutation: 21 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 1 reference(s)