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Targeted Allele Detail
Symbol: Casp12tm1Dgen
Name: caspase 12; targeted mutation 1, Deltagen
MGI ID: MGI:3604507
Gene: Casp12  Location: Chr9:5345430-5373032 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Alliance: Casp12tm1Dgen page
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Disruption caused by insertion of vector
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RNA transcripts are detectable in: brain, cerebellum, brainstem, spinal cord, eye, Harderian gland, heart, lung, liver, pancreas, kidney, spleen, thymus, lymph nodes, bone marrow, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, large intestine, cecum, testis, epididymis, seminal vesicle, coagulating gland, prostate gland, ovary, uterus and white fat. LacZ (beta-galactosidase) expression is detectable in brain, spinal cord, sciatic nerve, Harderian glands, spleen, lymph nodes, aorta, heart, lung, pancreas, kidney, urinary bladder, trachea, larynx, thyroid gland, parathyroid gland, adrenal glands, salivary glands, tongue, male and female reproductive systems. In many tissues, lacZ expression is detectable in blood vessels and ganglia.
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 108 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Casp12 Mutation:  20 strains or lines available
See also, data as provided by Deltagen, Inc.
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory