Tnfrsf12a^tm1Biib
Targeted Allele Detail

Summary

• Symbol: Tnfrsf12a^tm1Biib
• Name: tumor necrosis factor receptor superfamily, member 12a; targeted mutation 1, Biogen Idec
• MGI ID: MGI:3603146
• Synonyms: Fn14^-, Fn 14 knockout, Tnfrsf12a^tm1Ajak
• Gene: Tnfrsf12a Location: Chr17:23894419-23896423 bp, - strand Genetic Position: Chr17, 11.99 cM
• Alliance: Tnfrsf12a^tm1Biib page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100907
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to remove the first two exons, which encode the entire extracellular ligand-binding domain. Northern blot and RT-PCR confirmed the null mutation. (J:100907)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf12a Mutation: 8 strains or lines available

References

• Original: J:100907 Jakubowski A, et al., TWEAK induces liver progenitor cell proliferation. J Clin Invest. 2005 Sep 1;115(9):2330-2340
• All: 29 reference(s)