Creb3l4^tm1Imad
Targeted Allele Detail

Summary

• Symbol: Creb3l4^tm1Imad
• Name: cAMP responsive element binding protein 3-like 4; targeted mutation 1, Ibrahim M Adham
• MGI ID: MGI:3589381
• Synonyms: Creb3l4^-
• Gene: Creb3l4 Location: Chr3:90144807-90150819 bp, - strand Genetic Position: Chr3, 39.21 cM
• Alliance: Creb3l4^tm1Imad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100527
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.0-kb fragment of sequence encompassing exons 1a to 4 was replaced with GFP and a PGK-neomycin resistance cassette. Testes were analyzed by Northern blot, revealing no expression in mutants. GFP expression, however, was detected strongly in adult testes. (J:100527)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Creb3l4 Mutation: 23 strains or lines available

References

• Original: J:100527 Adham IM, et al., Reduction of spermatogenesis but not fertility in Creb3l4-deficient mice. Mol Cell Biol. 2005 Sep;25(17):7657-64
• All: 1 reference(s)