Abcc3^tm1Bor
Targeted Allele Detail

Summary

• Symbol: Abcc3^tm1Bor
• Name: ATP-binding cassette, sub-family C member 3; targeted mutation 1, Piet Borst
• MGI ID: MGI:3582301
• Synonyms: Mrp3^-
• Gene: Abcc3 Location: Chr11:94234121-94283823 bp, - strand Genetic Position: Chr11, 58.9 cM
• Alliance: Abcc3^tm1Bor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149653
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 4.9 kb of sequence containing exons 2-8, encoding amino acids 16-331, was replaced with a hygromycin resistance gene driven by Pgk1, and resulted in a frame shift that led to an early stop codon immediately after exon 1. Immunoblotting of various tissues in mutants demonstrated the absence of protein. (J:99480, J:149653)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc3 Mutation: 72 strains or lines available

References

• Original: J:149653 Zelcer N, et al., Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. J Hepatol. 2006 Apr;44(4):768-75
• All: 7 reference(s)