Agrn^tm5Jrs
Targeted Allele Detail

Summary

• Symbol: Agrn^tm5Jrs
• Name: agrin; targeted mutation 5, Joshua R Sanes
• MGI ID: MGI:3578923
• Synonyms: SN-Agrn
• Gene: Agrn Location: Chr4:156249747-156281945 bp, - strand Genetic Position: Chr4, 88.55 cM
• Alliance: Agrn^tm5Jrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220073
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced the short isoform-specific exon. Cre-mediated recombination removed the selection cassette. In situ hybridization confimred the absence of the short isoform in the hippocampus. (J:220073)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agrn Mutation: 101 strains or lines available

References

• Original: J:220073 Rauch SM, et al., Changes in brain beta-amyloid deposition and aquaporin 4 levels in response to altered agrin expression in mice. J Neuropathol Exp Neurol. 2011 Dec;70(12):1124-37
• All: 1 reference(s)