Ossc1^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Ossc1^C3H/HeJ
• Name: osteosarcoma susceptibility 1; C3H/HeJ
• MGI ID: MGI:3577302
• QTL: Ossc1 Location: Chr7:51053025-51053223 bp Genetic Position: Chr7, cM position of peak correlated region/allele: 32.75 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers osteosarcoma susceptibility compared to 102/El. (J:75213)
• Inheritance: Not Specified

Notes

Animals with the C3H/HeJ-derived susceptibility allele at Ossc1 and the 102/El-derived susceptibility allele at Ossc2 exhibit significantly increased incidence of osteosarcomas.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:75213

47 female animals from a T Stock x (C3H/HeJ x 102/El)F1 population were treated with ²²⁷thorium at 100 days of age to induce osteosarcoma. 54 microsatellite markers were screened in these animals to identify QTLs associated with osteosarcoma susceptibility. Suggestive linkage was detected at 26 cM on mouse Chromosome 7 (LOD=1.37 at D7Mit145) and at 45 cM on mouse Chromsome 14 (LOD=105 at D14Mit219.)

When both loci were analyzed together as interacting QTL the LOD score increased to 3.48. The chromosome 7 QTL is designated Ossc1 (osteosarcoma susceptibility 1) and the chromosome 14 QTL is designated Ossc2 (osteosarcoma susceptibility 2). The 102/El-derived allele confers resistance to osteosarcomas at Ossc1 but confers susceptibility at Ossc2. 75% of ²²⁷thorium-treated animals with susceptibility alleles at both Ossc1 (C3H/HeJ-derived) and Ossc2 (102/El-derived) develop osteosarcoma. Potential candidate genes for Ossc1 are Bax (23 cM), Xrcc1 (5.5 cM), and Fosb (5 cM). A potential candidate gene for Ossc2 is Rb1 (41 cM).

References

• Original: J:75213 Rosemann M, et al., Bone tumorigenesis induced by alpha-particle radiation: mapping of genetic Loci influencing predisposition in mice. Radiat Res. 2002 Apr;157(4):426-34
• All: 1 reference(s)