Txnip^tm1Yu
Targeted Allele Detail

Summary

• Symbol: Txnip^tm1Yu
• Name: thioredoxin interacting protein; targeted mutation 1, Dae-Yeul Yu
• MGI ID: MGI:3574362
• Synonyms: VDUP1^-
• Gene: Txnip Location: Chr3:96465273-96469173 bp, + strand Genetic Position: Chr3, 41.93 cM, cytoband F2.2
• Alliance: Txnip^tm1Yu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96677
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence from exon 1 to 8 was replaced by a lacZ and neo. RT-PCR and Northern blot confirmed absence of transcript in mutant tissues. (J:96677)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txnip Mutation: 48 strains or lines available

References

• Original: J:96677 Lee KN, et al., VDUP1 is required for the development of natural killer cells. Immunity. 2005 Feb;22(2):195-208
• All: 10 reference(s)