Anxa4^{Gt(OST134786)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Anxa4^{Gt(OST134786)Lex}
• Name: annexin A4; gene trap OST134786, Lexicon Genetics
• MGI ID: MGI:3530283
• Synonyms: AIValpha^-, Anxa4^{Gt(neo)418Lex}
• Gene: Anxa4 Location: Chr6:86713822-86770566 bp, - strand Genetic Position: Chr6, 37.75 cM
• Alliance: Anxa4^{Gt(OST134786)Lex} page

Mutation origin

• Mutant Cell Line: OST134786
• Germline Transmission: Earliest citation of germline transmission: J:87727
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Hypomorph, Modified isoform(s))
• Mutation: Insertion of gene trap vector
• Mutation details: The gene locus produces three different transcript variants that express the same 35-kDa protein but differ in their upstream untranslated region (UTR). A gene trap inserted downstream of "exon a", a non-coding exon that lies 27 kb upstream from the first coding exon. This insertion disrupted the UTR for one transcript variant of the gene locus but left intact two other transcript variants. Homozygotes for this allele are hypomorphs with the only strong gene expression occurring in the intestinal tract while wild-type mice have strong gene expression in numerous tissues including heart, kidney, liver, lung, stomach, and the intestinal tract. (J:87727)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST134786	CG541486 ; (MGI Seq Detail)	3' RACE	Chr6:86729148-86731915 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  11 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Anxa4 Mutation: 22 strains or lines available

References

• Original: J:87727 Li B, et al., Intron disruption of the annexin IV gene reveals novel transcripts. J Biol Chem. 2003 Oct 31;278(44):43276-83
• All: 5 reference(s)