Mbd3l1^tm1Gpp
Targeted Allele Detail

Summary

• Symbol: Mbd3l1^tm1Gpp
• Name: methyl-CpG binding domain protein 3-like 1; targeted mutation 1, Gerd P Pfeifer
• MGI ID: MGI:3526075
• Synonyms: Mbd3l1^-
• Gene: Mbd3l1 Location: Chr9:18389655-18396594 bp, + strand Genetic Position: Chr9, 7.06 cM, cytoband A3
• Alliance: Mbd3l1^tm1Gpp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95173
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3, which encodes the entire open reading frame, was replaced with a neo, leaving only the 7 N-terminal codons of the gene intact. Absence of transcript was shown in mutant testis by RT-PCR analysis. (J:95173)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbd3l1 Mutation: 14 strains or lines available

References

• Original: J:95173 Jiang CL, et al., MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex. J Biol Chem. 2004 Dec 10;279(50):52456-64
• All: 2 reference(s)