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Ightm3.1Cog
Targeted Allele Detail
Summary
Symbol: Ightm3.1Cog
Name: immunoglobulin heavy chain complex; targeted mutation 3.1, Michel Cogne
MGI ID: MGI:3522204
Synonyms: delta hs3b4, delta hs3b/hs4, Rr152tm3.1Cog
Gene: Igh  Location: Chr12:113222388-115973574 bp, - strand  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71300
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis targeted mutation deletes a 6-kilobase genomic DNA segment containing hs3b (Rr155) and hs4 (Rr156), the two most distant of four 3' transcriptional enhancers residing within the approximately 26 kilobase locus control region downstream of the Igh complex (3'RR or Rr152). The original targeting event replaced hs3b and hsb4 with a loxP-flanked neomycin resistance gene cassette. Crossing of chimeric founder mice with mice expressing Cre recombinase under control of the EIIa promoter yielded progeny in which the neo cassette was deleted in the germline. (J:71300)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  44 strains or lines available
References
Original:  J:71300 Pinaud E, et al., Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination. Immunity. 2001 Aug;15(2):187-99
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory