Rr185^tm3Cog
Targeted Allele Detail

Summary

• Symbol: Rr185^tm3Cog
• Name: regulatory region 185; targeted mutation 3, Michel Cogne
• MGI ID: MGI:3522200
• Synonyms: Igh^tm3Cog, Nhs3b4
• Gene: Rr185 Location: unknown Genetic Position: Chr12, Syntenic
• Alliance: Rr185^tm3Cog page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71300
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Modified regulatory region, No functional change)
• Mutation: Intragenic deletion
• Mutation details: This targeted mutation substitutes a 6-kilobase genomic DNA segment containing hs3b (Rr155) and hs4 (Rr156), the two most distant of four 3' transcriptional enhancers residing within the approximately 26 kb locus control region downstream of the Igh complex, with a loxP-flanked neomycin resistance gene cassette. (J:71300)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr185 Mutation: 0 strains or lines available

References

• Original: J:71300 Pinaud E, et al., Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination. Immunity. 2001 Aug;15(2):187-99
• All: 1 reference(s)