Srgn^tm1Mabr
Targeted Allele Detail

Summary

• Symbol: Srgn^tm1Mabr
• Name: serglycin; targeted mutation 1, Magnus Abrink
• MGI ID: MGI:3057187
• Synonyms: Sg^-
• Gene: Srgn Location: Chr10:62329612-62363224 bp, - strand Genetic Position: Chr10, 32.42 cM, cytoband B4
• Alliance: Srgn^tm1Mabr page

Srgn^tm1Mabr/Srgn^tm1Mabr peritoneal mast cells contain large empty vesicles

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93338
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and the regulatory sequences were replaced with a neomycin resistance cassette in reverse orientation to transcription. RT-PCR of spleens from mutant mice indicated a lack of protein. (J:93338)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srgn Mutation: 17 strains or lines available

References

• Original: J:93338 Abrink M, et al., Serglycin is essential for maturation of mast cell secretory granule. J Biol Chem. 2004 Oct 24;279(39):40897-905
• All: 17 reference(s)