Tg(MCP-DAF)227Nmp
Transgene Detail

Summary

• Symbol: Tg(MCP-DAF)227Nmp
• Name: transgene insertion 227, R & D Center, Nippon Meat Packers, Inc
• MGI ID: MGI:3055126
• Synonyms: Tg(DAF)227Nmp
• Transgene: Tg(MCP-DAF)227Nmp Location: unknown
• Alliance: Tg(MCP-DAF)227Nmp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MCP-DAF)227Nmp expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD55 (1604)

  Cd55	(MGI:104850)
  Cd55b	(MGI:104849)

• Mutation details: A minigene encoding human decay accelerating factor for complement (CD55, Cromer blood group system) (DAF) is expressed under control of the promoter of the porcine membrane cofactor protein/CD46, trophoblast-lymphocyte (MCP) gene. Immunohistochemistry revealed high levels of human DAF expression in the vascular endothelia and nerves of all organs examined, as well as on peripheral blood erythrocytes. Splenocytes and erythrocytes resisted lysis by human serum in an expression level-dependent manner, and hearts from transgenic mice functioned longer upon perfusion with human serum than did those of controls. (J:92493)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:92493 Murakami H, et al., Porcine MCP gene promoter directs high level expression of human DAF (CD55) in transgenic mice. Immunobiology. 2000 Apr;201(5):583-97
• All: 1 reference(s)