Myocd^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Myocd^tm1Eno
• Name: myocardin; targeted mutation 1, Eric N Olson
• MGI ID: MGI:3052940
• Synonyms: myocardin^-
• Gene: Myocd Location: Chr11:65067387-65160815 bp, - strand Genetic Position: Chr11, 40.42 cM
• Alliance: Myocd^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84789
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A promoterless lacZ gene and a neomycin selection cassette replaced exons 8 and 9, which encode the basic domain, the glutamine-rich domain and part of the SAP domain. These domains are required for the normal function of the gene. RT-PCR analysis demonstrated that no detectable transcript was expressed from this allele in homozygous mice. (J:84789)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myocd Mutation: 55 strains or lines available

References

• Original: J:84789 Li S, et al., The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9366-70
• All: 4 reference(s)