Pias4^tm1Hwu
Targeted Allele Detail

Summary

• Symbol: Pias4^tm1Hwu
• Name: protein inhibitor of activated STAT 4; targeted mutation 1, Hong Wu
• MGI ID: MGI:3046514
• Synonyms: Piasy^-
• Gene: Pias4 Location: Chr10:80989795-81003554 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Pias4^tm1Hwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91085
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of the coding region, exons 3 - 11, was replaced with a neo gene via homologous recombination. RT-PCR and western blot analysis confirmed the absence on RNA and protein expression in homozygous mutants (J:91085)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pias4 Mutation: 27 strains or lines available

References

• Original: J:91085 Wong KA, et al., Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Mol Cell Biol. 2004 Jun;24(12):5577-86
• All: 2 reference(s)