Ptpn2tm1Mtr
Targeted Allele Detail
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Symbol: |
Ptpn2tm1Mtr |
Name: |
protein tyrosine phosphatase, non-receptor type 2; targeted mutation 1, Michel L Tremblay |
MGI ID: |
MGI:3044910 |
Synonyms: |
tc-ptp-, tcptp- |
Gene: |
Ptpn2 Location: Chr18:67798581-67857665 bp, - strand Genetic Position: Chr18, 40.06 cM
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Alliance: |
Ptpn2tm1Mtr page
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Decreased number of stromal cells in Ptpn2tm1Mtr/Ptpn2tm1Mtr bone marrow
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:42595
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance gene replaced 1.5 exons which encoded amino acids 64-121. This rendered the gene product enzymatically nonfunctional. Lack of gene transcription was demonstrated by Northern blot analysis and absence of protein was confirmed by Western blot.
(J:42595)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ptpn2 Mutation: |
43 strains or lines available
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Original: |
J:42595 You-Ten KE, et al., Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice. J Exp Med. 1997 Aug 29;186(5):683-93 |
All: |
17 reference(s) |
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