Crlf2^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Crlf2^tm1Jni
• Name: cytokine receptor-like factor 2; targeted mutation 1, James N Ihle
• MGI ID: MGI:3039288
• Synonyms: Tslpr^-
• Gene: Crlf2 Location: Chr5:109702575-109706859 bp, - strand Genetic Position: Chr5, 53.24 cM
• Alliance: Crlf2^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89031
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a neomycin resistance gene oriented in the direction opposite of endogenous gene transcription via homologous recombination. Northern blotting confirmed that no detectable transcript was produced from this allele in homozygous mutants. (J:89031)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crlf2 Mutation: 21 strains or lines available

References

• Original: J:89031 Carpino N, et al., Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development. Mol Cell Biol. 2004 Mar;24(6):2584-92
• All: 62 reference(s)