Ifng^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Ifng^tm1Yiw
• Name: interferon gamma; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:3036127
• Synonyms: GKO, IFN-gamma^-, IFNgammaKO
• Gene: Ifng Location: Chr10:118276951-118281797 bp, + strand Genetic Position: Chr10, 66.75 cM
• Alliance: Ifng^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41632
• Parent Cell Line: A3-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ gene followed by a neomycin resistance gene replaced exon 1 starting at the initiation codon through part of intron 1. Northern blot analysis failed to detect mRNA in appropriately stimulated spleen cells and protein product could not be detected immunologically. (J:41632)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Ifng Mutation: 47 strains or lines available

References

• Original: J:41632 Tagawa Y, et al., Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes. J Immunol. 1997 Aug 1;159(3):1418-28
• All: 70 reference(s)