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Targeted Allele Detail
Symbol: Ifngtm1Yiw
Name: interferon gamma; targeted mutation 1, Yoichiro Iwakura
MGI ID: MGI:3036127
Synonyms: GKO, IFN-gamma-, IFNgammaKO
Gene: Ifng  Location: Chr10:118276951-118281797 bp, + strand  Genetic Position: Chr10, 66.75 cM
Alliance: Ifngtm1Yiw page
Germline Transmission:  Earliest citation of germline transmission: J:41632
Parent Cell Line:  A3-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ gene followed by a neomycin resistance gene replaced exon 1 starting at the initiation codon through part of intron 1. Northern blot analysis failed to detect mRNA in appropriately stimulated spleen cells and protein product could not be detected immunologically. (J:41632)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ifng Mutation:  41 strains or lines available
Original:  J:41632 Tagawa Y, et al., Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes. J Immunol. 1997 Aug 1;159(3):1418-28
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory