Malt1^tm1Vmd
Targeted Allele Detail

Summary

• Symbol: Malt1^tm1Vmd
• Name: MALT1 paracaspase; targeted mutation 1, Vishva M Dixit
• MGI ID: MGI:2684761
• Synonyms: paracaspase^-
• Gene: Malt1 Location: Chr18:65564010-65612138 bp, + strand Genetic Position: Chr18, 38.56 cM
• Alliance: Malt1^tm1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86770
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neomycin resistance gene was placed in intron 10 and an additional loxP site was placed in intron 12. Transient transfection of correctly targeted ES cells with a plasmid expressing Cre-recombinase eliminated the neomycin gene along with exons 11 and 12. Absence of protein product in resulting homozygous mice was demonstrated by Western blot analysis. (J:86770)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Malt1 Mutation: 33 strains or lines available

References

• Original: J:86770 Ruefli-Brasse AA, et al., Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science. 2003 Nov 28;302(5650):1581-4
• All: 8 reference(s)