Tyr^c-em
Spontaneous Allele Detail

Summary

• Symbol: Tyr^c-em
• Name: tyrosinase; extreme dilution mottled
• MGI ID: MGI:2683485
• Gene: Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
• Alliance: Tyr^c-em page

Mutation origin

• Strain of Origin: Harwell Tyr^c-m stock

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: Genomic analysis showed a c.1118C>T nucleotide substitution within the coding region resulting in a threonine to isoleucine amino acid change at position 373 (p.T373I) that abolishes an N-glycosylation sequon located in the second metal ion binding site of tyrosinase. (J:105054)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Tyr Mutation: 375 strains or lines available

Notes

Genbank ID for this allele: AY526904

References

• Original: J:13834 Phillips RJS, Modification of c-locus alleles - Mcm. Mouse News Lett. 1980;62:51-2
• All: 3 reference(s)