Ghrl^tm1Rgs
Targeted Allele Detail

Summary

• Symbol: Ghrl^tm1Rgs
• Name: ghrelin; targeted mutation 1, Roy G Smith
• MGI ID: MGI:2681803
• Synonyms: Ghrelin-
• Gene: Ghrl Location: Chr6:113693080-113696841 bp, - strand Genetic Position: Chr6, 52.84 cM, cytoband E3
• Alliance: Ghrl^tm1Rgs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86432
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a lacZ/neomycin selection cassette. mRNA analysis and immunohistochemistry confirmed the absence of gene product. (J:86432)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghrl Mutation: 7 strains or lines available

References

• Original: J:86432 Sun Y, et al., Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol. 2003 Nov;23(22):7973-81
• All: 26 reference(s)