Slc22a2^tm1Ahs
Targeted Allele Detail

Summary

• Symbol: Slc22a2^tm1Ahs
• Name: solute carrier family 22 (organic cation transporter), member 2; targeted mutation 1, Alfred H Schinkel
• MGI ID: MGI:2680270
• Synonyms: Oct2^-
• Gene: Slc22a2 Location: Chr17:12803076-12847376 bp, + strand Genetic Position: Chr17, 8.61 cM
• Alliance: Slc22a2^tm1Ahs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86270
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, as well as upstream sequence, was replaced with a neomycin selection cassette inserted by homologous recombination. Exon 1 encoded the start codon, the putative TMD1 domain, and the extracellular loop between the putative TMD1 and TMD2 domains. Transcript was undetected in homozygous mutant mice by Northern blot analysis of total kidney RNA. (J:86270)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc22a2 Mutation: 39 strains or lines available

References

• Original: J:86270 Jonker JW, et al., Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations. Mol Cell Biol. 2003 Nov;23(21):7902-8
• All: 7 reference(s)