Irak4^tm1Yeh
Targeted Allele Detail

Summary

• Symbol: Irak4^tm1Yeh
• Name: interleukin-1 receptor-associated kinase 4; targeted mutation 1, Wen-Chen Yeh
• MGI ID: MGI:2676448
• Synonyms: IRAK^-, Irak-4^-, IRAK-4 KO
• Gene: Irak4 Location: Chr15:94441495-94466198 bp, + strand Genetic Position: Chr15, 48.55 cM, cytoband F1
• Alliance: Irak4^tm1Yeh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76098
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which contains the start codon, was replaced with a neomycin selection cassette inserted by homologous recombination. Although mutant transcript was detected by RT-PCR analysis using C-terminal primers, neither normal nor truncated protein was undetected by Western blot analysis of MEFs derived from homozygous mutant mice. (J:76098)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irak4 Mutation: 30 strains or lines available

References

• Original: J:76098 Suzuki N, et al., Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature. 2002 Apr 18;416(6882):750-6
• All: 17 reference(s)