Ablim1^tm1Tili
Targeted Allele Detail

Summary

• Symbol: Ablim1^tm1Tili
• Name: actin-binding LIM protein 1; targeted mutation 1, Tiansen Li
• MGI ID: MGI:2676007
• Synonyms: abLIM-L -
• Gene: Ablim1 Location: Chr19:57021165-57303351 bp, - strand Genetic Position: Chr19, 52.09 cM
• Alliance: Ablim1^tm1Tili page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84905
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Modified isoform(s), Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Elimination of the retina-specific L isoform was accomplished by replacing all of exon 1 and 18 bp of intron 1 with a cassette containing IRES-lacZ and MC1-neo. RT-PCR analysis of homozygous mutant mice showed that while transcripts encoding the M and S isoforms were present, transcript encoding the L isoform was absent. Reporter expression was observed but sporadic. (J:84905)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ablim1 Mutation: 54 strains or lines available

References

• Original: J:84905 Lu C, et al., Normal retinal development and retinofugal projections in mice lacking the retina-specific variant of actin-binding LIM domain protein. Neuroscience. 2003;120(1):121-31
• All: 1 reference(s)