About   Help   FAQ
Chemically induced Allele Detail
Symbol: Nle1l11Jus1
Name: notchless homolog 1; lethal, Chr 11, Justice 1
MGI ID: MGI:2671871
Synonyms: l11Jus01
Gene: Nle1  Location: Chr11:82791594-82799237 bp, - strand  Genetic Position: Chr11, 50.3 cM
Alliance: Nle1l11Jus1 page
Strain of Origin:  C57BL/6J
Project Collection: Mutagenesis for Dev. Defects
Allele Type:    Chemically induced (ENU)
Mutation:    Nucleotide substitutions
Mutation detailsThis phenotypic mutant was identified in an ENU mutagenesis screen at the Baylor College of Medicine. The molecular lesion is a c.1187T>G transversion mutation (p.I396S change in the encoded protein) in l11Jus1 heterozygotes in exon 10. This non-conservative substitution replaces an aliphatic, hydrophobic amino acid with a polar residue, which likely disrupts functionality. In addition, an endogenous C57BL/6J non-synonymous SNP rs13468707 (c.538A>G transition; p.I180V) is present in exon 6. This is the equivalent of well-documented human SNP rs2820949 and leads to a very conservative amino acid substitution. Thus, l11Jus1 homozygotes harbor two coding changes in this gene: an ENU-induced point mutation and an additional spontaneous missense mutation that is also present in the C57BL/6J parent strain. (J:193532)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nle1 Mutation:  27 strains or lines available
Original:  J:85113 Kile BT, et al., Functional genetic analysis of mouse chromosome 11. Nature. 2003 Sep 4;425(6953):81-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.23
The Jackson Laboratory