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Targeted Allele Detail
Symbol: Prdx6tm1Pgn
Name: peroxiredoxin 6; targeted mutation 1, Beverly Paigen
MGI ID: MGI:2668338
Synonyms: Prdx6-
Gene: Prdx6  Location: Chr1:161067682-161078780 bp, - strand  Genetic Position: Chr1, 69.75 cM
Alliance: Prdx6tm1Pgn page
Germline Transmission:  Earliest citation of germline transmission: J:84376
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2 were replaced with a neomycin drug resistance gene and a lacZ gene. RT-PCR demonstrated the absence of mRNA in the livers of homozygotes while the absence of protein was proven by Western blot and by immunohistochemistry. (J:84376)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Prdx6 Mutation:  44 strains or lines available
Original:  J:84376 Wang X, et al., Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J Biol Chem. 2003 Jul 4;278(27):25179-90
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory