Lyz2^tm1.1Graf
Targeted Allele Detail

Summary

• Symbol: Lyz2^tm1.1Graf
• Name: lysozyme 2; targeted mutation 1.1, Thomas Graf
• MGI ID: MGI:2654931
• Synonyms: EGFP-lys, lys M^-, LysM-eGFP, LysM-GFP⁺, Lyz2^GFP, Tg(LysMeGFP)
• Gene: Lyz2 Location: Chr10:117113446-117118177 bp, - strand Genetic Position: Chr10, 65.34 cM
• Alliance: Lyz2^tm1.1Graf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63254
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: This allele is derived from Lyz2^tm1Graf by mating to cre deleter line Tg(CMV-cre)1Cgn to remove the floxed neo cassette. Homozygous mutant animals retain the EGFP knock-in cassette in exon 1 directly downstream of the translation initiation codon. (J:63254)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lyz2 Mutation: 41 strains or lines available

References

• Original: J:63254 Faust N, et al., Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages. Blood. 2000 Jul 15;96(2):719-26
• All: 136 reference(s)