Nqo2^tm1Akj
Targeted Allele Detail

Summary

• Symbol: Nqo2^tm1Akj
• Name: N-ribosyldihydronicotinamide quinone reductase 2; targeted mutation 1, Anil K Jaiswal
• MGI ID: MGI:2447336
• Synonyms: NQO2-
• Gene: Nqo2 Location: Chr13:34148670-34172426 bp, + strand Genetic Position: Chr13, 14.01 cM, cytoband A4
• Alliance: Nqo2^tm1Akj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80549
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.1 kb fragment encompassing exon 3 and portions of the surrounding introns was replaced by a neo cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern or Western blot analyses of liver, kidney, testis, and lung tissue obtained from homozygous mutant mice. Assays of benzo(alpha)pyrene-sensitive Nqo2 activity showed levels to be almost completely abrogated in kidney, testes, and lung samples and reduced by approximately 80% in liver samples. The authors report that the residual activity in the liver is believed to be the result of related proteins. (J:80549)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nqo2 Mutation: 21 strains or lines available

References

• Original: J:80549 Long DJ 2nd, et al., Disruption of Dihydronicotinamide Riboside:Quinone Oxidoreductase 2 (NQO2) Leads to Myeloid Hyperplasia of Bone Marrow and Decreased Sensitivity to Menadione Toxicity. J Biol Chem. 2002 Nov 29;277(48):46131-9
• All: 7 reference(s)