Per2^tm1Ccl
Targeted Allele Detail

Summary

• Symbol: Per2^tm1Ccl
• Name: period circadian clock 2; targeted mutation 1, Cheng Chi Lee
• MGI ID: MGI:2388602
• Synonyms: mPer2^-
• Gene: Per2 Location: Chr1:91343704-91387046 bp, - strand Genetic Position: Chr1, 46.13 cM, cytoband C5
• Alliance: Per2^tm1Ccl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79456
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 5.5 kb of sequence encompassing the entire PAS B domain was replaced by the insertion of a neomycin selection cassette. Splicing of the remaining exons putatively generates a frameshift mutation affecting sequence downstream of exon 11. (J:79456)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Per2^tm1Ccl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Per2 Mutation: 71 strains or lines available

References

• Original: J:79456 Fu L, et al., The circadian gene period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell. 2002 Oct 4;111(1):41
• All: 10 reference(s)