Lpar2^tm1Jch
Targeted Allele Detail

Summary

• Symbol: Lpar2^tm1Jch
• Name: lysophosphatidic acid receptor 2; targeted mutation 1, Jerold Chun
• MGI ID: MGI:2387979
• Synonyms: lpa2-, Lpar2^-
• Gene: Lpar2 Location: Chr8:70275215-70283752 bp, + strand Genetic Position: Chr8, 33.91 cM
• Alliance: Lpar2^tm1Jch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78925
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' portion of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded transmembrane domains 4 through 6 and the splice donor site. Transcript was undetected in kidney and testes tissue by Northern blot and RT-PCR analyses of homozygous mutant mice. (J:78925)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lpar2 Mutation: 13 strains or lines available

References

• Original: J:78925 Contos JJ, et al., Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol Cell Biol. 2002 Oct;22(19):6921-9
• All: 24 reference(s)