Rpgrtm1Tili
Targeted Allele Detail
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Symbol: |
Rpgrtm1Tili |
Name: |
retinitis pigmentosa GTPase regulator; targeted mutation 1, Tiansen Li |
MGI ID: |
MGI:2386674 |
Synonyms: |
RPGR- |
Gene: |
Rpgr Location: ChrX:10024455-10083034 bp, - strand Genetic Position: ChrX, 4.62 cM
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Alliance: |
Rpgrtm1Tili page
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Light micrographs of retinal sections of wild-type and Rpgrtm1Tili/Rpgrtm1Tili mice.
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:61371
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Part of exon 4 through part of exon 6 was replaced with a promoter-less lacZ-neo cassette via homologous recombination. Northern blot analysis using a full length cDNA probe did not detect gene expression in brains from homozygous mutant animals. RT-PCR analysis also did not detect gene transcripts. Western blot analysis of protein from brain, retina, and testis confirmed the null allele.
(J:61371)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rpgr Mutation: |
8 strains or lines available
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Original: |
J:61371 Hong DH, et al., A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3). Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3649-54 |
All: |
17 reference(s) |
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