Kcna4^tm1Lndn
Targeted Allele Detail

Summary

• Symbol: Kcna4^tm1Lndn
• Name: potassium voltage-gated channel, shaker-related subfamily, member 4; targeted mutation 1, Barry London
• MGI ID: MGI:2386331
• Synonyms: Kv1.4^-
• Gene: Kcna4 Location: Chr2:107120984-107128847 bp, + strand Genetic Position: Chr2, 56.12 cM, cytoband E
• Alliance: Kcna4^tm1Lndn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48415
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of a large part of the coding region with a PGK-neo cassette resulting in the deletion of the N-terminal multimerization domain. Northern blot analysis of brain RNA from homozygous mutant animals detected a truncated transcript, and Western blot analysis failed to detect the 85 kDa protein in the heart or brain. However, a 65 kDa protein was detected that may possibly be another channel protein that cross-reacts with the anti-Kcna4 antibody. (J:48415)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcna4 Mutation: 31 strains or lines available

References

• Original: J:48415 London B, et al., The transient outward current in mice lacking the potassium channel gene Kv1.4. J Physiol. 1998 May 15;509(Pt 1):171-82
• All: 10 reference(s)