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Targeted Allele Detail
Symbol: Eportm1.4Jtp
Name: erythropoietin receptor; targeted mutation 1.4, Josef T Prchal
MGI ID: MGI:2386099
Synonyms: EporTr, mthEPOR
Gene: Epor  Location: Chr9:21870193-21874802 bp, - strand  Genetic Position: Chr9, 7.93 cM
Alliance: Eportm1.4Jtp page
Germline Transmission:  Earliest citation of germline transmission: J:67205
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
Eportm1.4Jtp expresses 1 gene
Mutation detailsThis allele is a derivative of Eportm1.3Jtp in which cre-mediated recombination in vivo removed the PGK-neo cassette in the germline. The resulting allele, Eportm1.4Jtp, contains human sequence carrying a C5964G transversion mutation in exon 8. RT-PCR analysis of bone marrow detected truncated human transcript in homozygous mutant mice. (J:67205)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epor Mutation:  18 strains or lines available
Original:  J:67205 Divoky V, et al., Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):986-91
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory