Tcrd-V1^tm1Kjk
Targeted Allele Detail

Summary

• Symbol: Tcrd-V1^tm1Kjk
• Name: T cell receptor delta, variable 1; targeted mutation 1, Kenji Kishihara
• MGI ID: MGI:2385954
• Synonyms: TCR Vdelta1 KO, Vdelta1^-
• Gene: Tcrd-V1 Location: Chr14:54311452-54312737 bp Genetic Position: Chr14, Syntenic
• Alliance: Tcrd-V1^tm1Kjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64863
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a floxed PGK-neo cassette via homologous recombination. Prior to blastocyst injection, the PGK-neo cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Southern blotting confirmed correct targeting of construct. (J:64863)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcrd-V1 Mutation: 0 strains or lines available

References

• Original: J:64863 Hara H, et al., Development of dendritic epidermal T cells with a skewed diversity of gammadeltaTCRs in Vdelta1-deficient mice. J Immunol. 2000 Oct 1;165(7):3695-705
• All: 11 reference(s)