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Scnn1atm1.1Hum
Targeted Allele Detail
Summary
Symbol: Scnn1atm1.1Hum
Name: sodium channel, nonvoltage-gated 1 alpha; targeted mutation 1.1, Edith Hummler
MGI ID: MGI:2384527
Synonyms: Scnn1aflox, Scnn1alox
Gene: Scnn1a  Location: Chr6:125297622-125321906 bp, + strand  Genetic Position: Chr6, 59.32 cM
Alliance: Scnn1atm1.1Hum page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75110
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 1 of the gene was flanked by an upstream loxP site and a downstream floxed neo cassette. Expression of Cre recombinase in ES cells resulted in the excision of the floxed neo cassette, leaving exon 1 surrounded by single loxP sites. Expression analysis showed that transcript levels were normal. (J:75110)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scnn1a Mutation:  27 strains or lines available
References
Original:  J:75110 Hummler E, et al., Conditional gene targeting of the Scnn1a (alphaENaC) gene locus. Genesis. 2002 Feb;32(2):169-72
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory