Fes^tm1Mcs
Targeted Allele Detail

Summary

• Symbol: Fes^tm1Mcs
• Name: feline sarcoma oncogene; targeted mutation 1, M Celeste Simon
• MGI ID: MGI:2182586
• Synonyms: c-fes^-
• Gene: Fes Location: Chr7:80027504-80037694 bp, - strand Genetic Position: Chr7, 45.65 cM
• Alliance: Fes^tm1Mcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64748
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter and translation initiation codon were replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant embryonic stem cells were identified by Southern blot analysis and Western blot analysis was used to confirm the absence of gene expression. (J:64748)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fes Mutation: 40 strains or lines available

References

• Original: J:64748 Hackenmiller R, et al., Abnormal Stat activation, hematopoietic homeostasis, and innate immunity in c-fes-/- mice. Immunity. 2000 Sep;13(3):397-407
• All: 1 reference(s)