Hspa1b^tm1Clib
Targeted Allele Detail

Summary

• Symbol: Hspa1b^tm1Clib
• Name: heat shock protein 1B; targeted mutation 1, Claude Libert
• MGI ID: MGI:2180762
• Synonyms: hsp70.1^-
• Gene: Hspa1b Location: Chr17:35175412-35178214 bp, - strand Genetic Position: Chr17, 18.5 cM
• Alliance: Hspa1b^tm1Clib page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76801
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette via homologous recombination. The mutant allele was verified by Northern blot analysis of mouse embryonic fibroblasts cultured from homozygous mutant animals. (J:76801)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspa1b Mutation: 23 strains or lines available

References

• Original: J:76801 Van Molle W, et al., HSP70 protects against TNF-induced lethal inflammatory shock. Immunity. 2002 May;16(5):685-95
• All: 3 reference(s)