Cebpatm1Kgx
Targeted Allele Detail
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Symbol: |
Cebpatm1Kgx |
Name: |
CCAAT/enhancer binding protein alpha; targeted mutation 1, Kleanthis G Xanthopoulos |
MGI ID: |
MGI:2177068 |
Synonyms: |
Cebpa-, C/EBPalpha- |
Gene: |
Cebpa Location: Chr7:34818718-34821353 bp, + strand Genetic Position: Chr7, 21.02 cM
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Alliance: |
Cebpatm1Kgx page
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Abnormal liver and lung morphology in Cebpatm1Kgx/Cebpatm1Kgx mice
Show the 1 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A neomycin resistance cassette was inserted downstream of both translation initiation codons, resulting in stop codons in all three reading frames. Northern blot analysis on RNA derived from liver of homozygous mice demonstrated that a large fusion transcript was made that incorporated both the gene and the neomycin cassette elements. However, western blot experiments on liver lysates from homozygous mice confirmed that no detectable protein was expressed from this allele.
(J:35795)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cebpa Mutation: |
16 strains or lines available
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Original: |
J:35795 Flodby P, et al., Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J Biol Chem. 1996 Oct 4;271(40):24753-60 |
All: |
5 reference(s) |
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