Ucp2^tm1Rcq
Targeted Allele Detail

Summary

• Symbol: Ucp2^tm1Rcq
• Name: uncoupling protein 2 (mitochondrial, proton carrier); targeted mutation 1, Daniel Ricquier
• MGI ID: MGI:2176053
• Synonyms: Ucp2-
• Gene: Ucp2 Location: Chr7:100142565-100148832 bp, + strand Genetic Position: Chr7, 54.36 cM
• Alliance: Ucp2^tm1Rcq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66262
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a PGK-neomycin resistance cassette deleted 119 bp of exon III downstream of the initiation codon, intron 3, and 68 bp of exon IV, and inserted a stop codon immediately downstream of the aa 13 codon. The deleted sequences encode amino acids 14-73. Western and Northern blot analyses did not detect expression in any tissues from homozygous mutant mice. (J:66262)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ucp2 Mutation: 40 strains or lines available

References

• Original: J:66262 Arsenijevic D, et al., Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet. 2000 Dec;26(4):435-9
• All: 27 reference(s)