Chrna4^tm1Lst
Targeted Allele Detail

Summary

• Symbol: Chrna4^tm1Lst
• Name: cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1, Henry A Lester
• MGI ID: MGI:2158758
• Synonyms: L9'S, Leu-9'Ser, neo-intact line
• Gene: Chrna4 Location: Chr2:180664104-180685339 bp, - strand Genetic Position: Chr2, 103.54 cM
• Alliance: Chrna4^tm1Lst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67863
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Point mutations were introduced into exon 5 to alter a residue in the fourth transmembrane domain from a leucine to a serine. A loxP flanked neomycin selection cassette was also inserted into an adjacent intron. (J:67863)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrna4 Mutation: 42 strains or lines available

References

• Original: J:67863 Labarca C, et al., Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2786-91
• All: 5 reference(s)