Trio^tm1Mst
Targeted Allele Detail

Summary

• Symbol: Trio^tm1Mst
• Name: triple functional domain (PTPRF interacting); targeted mutation 1, Michel Streuli
• MGI ID: MGI:2158695
• Synonyms: trio^-
• Gene: Trio Location: Chr15:27730737-28025934 bp, - strand Genetic Position: Chr15, 10.4 cM
• Alliance: Trio^tm1Mst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65380
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette was inserted into sequences encoding the amino-terminal GEF domain. Western blot analysis on immunoprecipitates of E14.5 embryonic cells derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:65380, J:112170)

Expression

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trio Mutation: 132 strains or lines available

References

• Original: J:65380 O'Brien SP, et al., Skeletal muscle deformity and neuronal disorder in trio exchange factor-deficient mouse embryos. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12074-8
• All: 6 reference(s)