Bmpr1b^{Tg(ACTB-FLP)4917Dym}
Transgenic Allele Detail

Summary

• Symbol: Bmpr1b^{Tg(ACTB-FLP)4917Dym}
• Name: bone morphogenetic protein receptor, type 1B; transgene insertion 4917, Susan Dymecki
• MGI ID: MGI:2158498
• Synonyms: 4917^Tg, ACTB:FLPe, BmprIB^Tg, FLPe deleter
• Gene: Bmpr1b Location: Chr3:141542897-141875186 bp, - strand Genetic Position: Chr3, 66.11 cM
• Alliance: Bmpr1b^{Tg(ACTB-FLP)4917Dym} page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Hypomorph, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Bmpr1b^{Tg(ACTB-FLP)4917Dym} expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ACTB (60)

  Actb	(MGI:87904)

• Mutation details: A random insertion of a transgene expressing Flp recombinase under the control of a human beta-actin promoter resulted in the mutation. Exon 1 and flanking sequence are deleted and replaced with two head-to-tail copies of the transgene. RT-PCR analysis on olfactory epithelium and limb tissue of homozygous mice revealed that this mutation results in the loss of transcript expression only in the limb. The authors propose that the use of two promoters in the gene can account for the partial loss, and that the mutation affects only one of these promoters. (J:59288, J:74965, J:86221)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	ACTB (human) Summary of all recombinase alleles driven by ACTB. Comparative matrix view of recombinase activities Alliance human ACTB gene page

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmpr1b Mutation: 37 strains or lines available

References

• Original: J:74965 Dymecki SM, Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6191-6
• All: 65 reference(s)