Mol1^BALB/cByJ
QTL Variant Detail

Summary

• QTL variant: Mol1^BALB/cByJ
• Name: modifier of LPS-response 1; BALB/cByJ
• MGI ID: MGI:2156744
• QTL: Mol1 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: BALB/cByJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased LPS response compared to C57BL/6ByJ. (J:58921)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:58921

The difference in the response to LPS (lipopolysaccharide) exhibited between C57BL/6J and A/J mice allowed for the mapping of QTls in AXB/BXA Recombinant Inbred strains. Four provisional modifers of the LPS response were mapped to mouse Chromosomes 1, 7, 11, and 13. Mol1 was localized to a 5 cM region flanked by markers D7Mit267 and D7Mit25. Moreover congenic strain B6.C-H24^cGpi^a/By HW24) expresed the Mol1 phenotype within a donor region that included markers D7Mit77, H24, and D7Mit310.

References

• Original: J:58921 Matesic LE, et al., Mapping lipopolysaccharide response loci in mice using recombinant inbred and congenic strains. Genomics. 1999 Nov 15;62(1):34-41
• All: 1 reference(s)