Lepr^db-rtnd
Spontaneous Allele Detail

Summary

• Symbol: Lepr^db-rtnd
• Name: leptin receptor; rotund
• MGI ID: MGI:2151178
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^db-rtnd page

Mutation origin

• Strain of Origin: CBA/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: There is a G residue deletion in exon 4 at nucleotide position 572, 573, 574, or 575. This causes a frameshift and premature translation stop. There is an almost 50% reduction in mRNA expression as compared to wild-type when assessed by semiquantitative RT-PCR. (J:83762)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 121 strains or lines available

References

• Original: J:83762 Kim JH, et al., New leptin receptor mutations in mice: Lepr(db-rtnd), Lepr(db-dmpg) and Lepr(db-rlpy). J Nutr. 2003 May;133(5):1265-71
• All: 1 reference(s)