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Ctslnkt
Radiation induced Allele Detail
Summary
Symbol: Ctslnkt
Name: cathepsin L; nackt
MGI ID: MGI:1889860
Synonyms: nkt
Gene: Ctsl  Location: Chr13:64509704-64518586 bp, - strand  Genetic Position: Chr13, 33.26 cM
Alliance: Ctslnkt page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Radiation induced
Mutation:    Intragenic deletion
 
Mutation detailsArose spontaneously in a stock derived from an irradiated founder in Germany in 1981. Molecular analysis of the coding region in nackt mice revealed a 118 bp deletion involving the end of exon 6 and almost all of exon 7. Western analysis of skin from homozygous mutant mice indicated that no stable protein is produced. (J:69924, J:108004)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 20 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ctsl Mutation:  29 strains or lines available
References
Original:  J:54856 Benavides F, et al., Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency. Immunogenetics. 1999 May;49(5):413-9
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory