Il12rb2^tm1Jm
Targeted Allele Detail

Summary

• Symbol: Il12rb2^tm1Jm
• Name: interleukin 12 receptor, beta 2; targeted mutation 1, Jeanne Magram
• MGI ID: MGI:1861950
• Synonyms: IL-12Rbeta2^-, IL-12Rbeta2KO
• Gene: Il12rb2 Location: Chr6:67268302-67353172 bp, - strand Genetic Position: Chr6, 30.81 cM
• Alliance: Il12rb2^tm1Jm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65891
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 2 and 3 of the gene, deleting the ATG translation initiation codon, the signal peptide, and the N-terminal immunoglobulin domain of the receptor. (J:65891)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il12rb2 Mutation: 48 strains or lines available

References

• Original: J:65891 Wu Cy, et al., IL-12 receptor ss2 (IL-12Rss2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. J Immunol. 2000 Dec 1;165(11):6221-8
• All: 75 reference(s)