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Ccd
Radiation induced Allele Detail
Summary
Symbol: Ccd
Name: cleidocranial dysplasia
MGI ID: MGI:1861187
Synonyms: 320
Gene: Ccd  Location: unknown  Genetic Position: Chr17, Syntenic
Alliance: Ccd page
Mutation
origin
Strain of Origin:  101
Mutation
description
Allele Type:    Radiation induced
Mutation:    Intergenic deletion
 
Mutation detailsGenetic analysis of Ccd mice showed a 2 cM deletion on chromosome 17 in an area of synteny to human 6p. The deletion is flanked on one side by the Tcte1 gene, involves Runx1, but extends further proximally, also deleting Mut. (J:40784)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccd Mutation:  0 strains or lines available
Notes
Induced by gamma irradiation in a 101 strain male. Heterozygotes show striking homology to cleidocranial dysplasia, a skeletal disorder in man. The mutation is fully penetrant in heterozygotes. It causes partial or complete failure of ossification of clavicles, symphysis pubis, and cranial fontanelles. This mutation is lethal in homozygotes (J:14006).
References
Original:  J:14006 Selby P, et al., Cleidocranial dysplasia, Ccd. Mouse News Lett. 1985;72:123
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/01/2024
MGI 6.24
The Jackson Laboratory