About   Help   FAQ
Radiation induced Allele Detail
Symbol: Ccd
Name: cleidocranial dysplasia
MGI ID: MGI:1861187
Synonyms: 320
Gene: Ccd  Location: unknown  Genetic Position: Chr17, Syntenic
Alliance: Ccd page
Strain of Origin:  101
Allele Type:    Radiation induced
Mutation:    Intergenic deletion
Mutation detailsGenetic analysis of Ccd mice showed a 2 cM deletion on chromosome 17 in an area of synteny to human 6p. The deletion is flanked on one side by the Tcte1 gene, involves Runx1, but extends further proximally, also deleting Mut. (J:40784)
Inheritance:    Semidominant
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccd Mutation:  0 strains or lines available
Induced by gamma irradiation in a 101 strain male. Heterozygotes show striking homology to cleidocranial dysplasia, a skeletal disorder in man. The mutation is fully penetrant in heterozygotes. It causes partial or complete failure of ossification of clavicles, symphysis pubis, and cranial fontanelles. This mutation is lethal in homozygotes (J:14006).
Original:  J:14006 Selby P, et al., Cleidocranial dysplasia, Ccd. Mouse News Lett. 1985;72:123
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory