Pik3cg^tm1Wym
Targeted Allele Detail

Summary

• Symbol: Pik3cg^tm1Wym
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; targeted mutation 1, Matthias P Wymann
• MGI ID: MGI:1858012
• Synonyms: p110gamma-, PI3Kgamma-, PI3Kgamma^KO
• Gene: Pik3cg Location: Chr12:32223472-32258658 bp, - strand Genetic Position: Chr12, 13.74 cM, cytoband B
• Alliance: Pik3cg^tm1Wym page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60349
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• An IRES-LacZ-neo cassette was inserted into exon 2 via homologous recombination. (J:60349)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3cg Mutation: 59 strains or lines available

References

• Original: J:60349 Hirsch E, et al., Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation [see comments]. Science. 2000 Feb 11;287(5455):1049-53
• All: 78 reference(s)